When an extravasation event is identified during a drug treatment, stop drug administration immediately and attempt to aspirate as much of the drug as possible from the tissues. Mark the extravasated area with a permanent pen. Upon removal of the catheter, begin specific treatment. Dexrazoxane administration is recommended within 6 hours of the extravasation event and may be repeated more than once although the precise schedule of treatment is not well defined. Tissue cooling by the application of cold compresses every 4-8 hours for several days is recommended to induce vasoconstriction and decrease the diffusion of the drug into adjacent tissues. Topical DMSO (90% concentration) and hydrocortisone cream (1%) application may also help to reduce tissue reactions. Photograph and monitor the site for progression of the drug induced injury which may take days to weeks to reach maximum severity. Analgesic therapy may be required. In severe tissue injury, surgical debridement may be necessary.